Article

Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma

2022-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma develops an immunosuppressive microenvironment that fosters tumorigenesis and resistance to current therapeutic strategies. Here we use multiplexed tissue imaging and single-cell RNA-sequencing to characterize the composition, spatial organization, and clinical significance of extracellular purinergic signaling in glioblastoma. We show that glioblastoma exhibit strong expression of...

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Literature Corpus work: 188b26d9-5dc7-59c5-bc2b-48ab318a7c16
DOI: 10.1101/2022.01.12.475925

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