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Dissecting T Cell Exhaustion in Non-Small Cell Lung Cancer: Single-Cell and Spatial Transcriptomics Reveal Prognostic Signatures and Therapeutic Implications

2025-10-06

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Non-small cell lung cancer (NSCLC) represents 85% of lung cancers and remains a leading cause of cancer death. Immunotherapy advancements have improved treatment, but many patients develop resistance due to T cell exhaustion. Understanding this mechanism, aided by single-cell RNA sequencing, is vital for creating personalized therapies. <bold>Methods:</bold>...

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Literature Corpus work: 0e056147-797b-5727-8506-d98bf9115a10
DOI: 10.21203/rs.3.rs-7434355/v1

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