Article

Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10

2020-09-16

Abstract excerpt

<h4>Summary</h4> Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) are heavily infiltrated by CD8+ tumor infiltrating lymphocytes (TILs) and are associated with a better prognosis than the majority of CRCs. The immunogenicity of dMMR CRCs is commonly attributed to abundant neoantigen generation due to their extreme genomic instability. However, lack of neoantigenic overlap between these and other...

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Literature Corpus work: ef4df602-30f6-57fc-b758-0319949fd6a8
DOI: 10.1101/2020.09.15.291765

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