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Article

Deficient Mismatch Repair and the Role of Immunotherapy in Metastatic Colorectal Cancer.

Current treatment options in oncology - 1 Aug 2016

Quiroga Dionisia, Lyerly H Kim, Morse Michael A

Abstract excerpt

OPINION STATEMENT: Division of colorectal cancers (CRCs) into molecular subsets yields important consequences for prognosis and therapeutic response. The microsatellite instability (MSI) immune subgroup, accounting for 15 % of early-stage and 3 % of metastatic CRCs, are a result of deficient cellular DNA mismatch repair (dMMR) mechanisms. dMMR CRCs are notable for greater survivability, yet lack of benefit from...

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Identifiers

PMID: 27315067
DOI: 10.1007/s11864-016-0414-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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