Article

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

2021-08-25

Abstract excerpt

DNA mismatch repair deficiency (MMRd) in human cancer is associated with high tumor mutational burden (TMB), frameshift mutation-derived neoantigens, increased T cell infiltration, and remarkable responsiveness to immune checkpoint blockade (ICB) therapy. Nevertheless, about half of MMRd tumors do not respond to ICB for unclear reasons. While tumor cell line transplant models of MMRd have reinforced the importance...

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Literature Corpus work: 111097aa-f62d-5b22-beee-d71101b5f981
DOI: 10.1101/2021.08.24.457572

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