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Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

2021-02-01

Abstract excerpt

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd patients. Analysis of 88 cell subsets and their 204 associated ge...

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Identifiers and source

Literature Corpus work
0f515f57-f53c-52c7-b452-8182887e1ea4
DOI
10.1101/2021.01.30.426796
Open publication

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Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancerDOI 10.1101/2021.01.30.426796
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