Article

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancer

2026-04-16

Abstract excerpt

<title>Abstract</title> <p> Among colorectal cancers (CRC), DNA mismatch repair-deficient (dMMR) tumors exhibit high mutational burden, increased immunogenicity, and better responsiveness to immune checkpoint blockade, when compared to MMR-proficient (pMMR) tumors. As a result, conventional T cells have been extensively studied in this disease, while the function of gδ T cells is understudied. Here, we report on...

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Literature Corpus work: 4e8e92d2-118c-503c-8ed2-8db42754ada7
DOI: 10.21203/rs.3.rs-9333190/v1

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