Article
Modulating the tumor immune phenotypes by radiotherapy: formulating and validating the combination therapy of radiation, PD-L1, and TIM-3 blockade in colorectal cancer.
Journal for immunotherapy of cancer - 24 Feb 2026
Wang Xuan Xuan, Zhu Chu, Sun Yikan, Xie Xuyun, Wang Mengjia, Jin Yue, Gu Yanjun, Qian Liwen, Shi Liming, Xu Jiaqi, Wang Fei, Huang Xuefeng, Dai Sheng, Sun Xiaonan
Abstract excerpt
BACKGROUND: Most colorectal cancers (CRCs) are mismatch repair-proficient (pMMR) and microsatellite stable (MSS), and they respond poorly to immune checkpoint inhibitors (ICIs). Radiotherapy (RT) can promote antitumor immunity but may also trigger adaptive immune suppression through checkpoint upregulation, providing a rationale for combination therapies. METHODS: We integrated transcriptomic analyses from The...
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