Article

Laquinimod treatment attenuates EAU by inhibiting both the inductive and effector phases in an APC-dependent manner

2025-05-25

Abstract excerpt

<h4>Purpose</h4> To evaluate the immunomodulatory effects on experimental autoimmune uveitis (EAU) of the aryl hydrocarbon receptor (AhR) agonist Laquinimod (LAQ), and its active metabolite DELAQ, with a focus on dendritic cell– and T cell–mediated mechanisms. <h4>Methods</h4> EAU was induced in mice by active immunization or by adoptive transfer of activated T cells. Mice were treated with LAQ either from the t...

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Literature Corpus work: ef4d8665-72f6-55ca-8eda-eb5c675abd8d
DOI: 10.1101/2025.05.20.654165

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