Article
Developmental Activation of the AHR Increases Effector CD4+ T Cells and Exacerbates Symptoms in Autoimmune Disease-Prone Gnaq+/- Mice.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2015
Boule Lisbeth A, Burke Catherine G, Fenton Bruce M, Thevenet-Morrison Kelly, Jusko Todd A, Lawrence B Paige
Abstract excerpt
Perinatal environmental exposures are potentially important contributors to the increase in autoimmune diseases. Yet, the mechanisms by which these exposures increase self-reactive immune responses later in life are poorly understood. Autoimmune diseases require CD4(+) T cells for initiation, progression, and/or clinical symptoms; thus, developmental exposures that cause durable changes in CD4(+) T cells may play...
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