Article

Melatonin, an Endogenous Hormone, Modulates Th17 Cells via the Reactive Oxygen Species/TXNIP/HIF-1α Axis to Alleviate Autoimmune Uveitis

2022-01-05

Abstract excerpt

<h4>Background: </h4> Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti-inflammatory properties of melatonin have attracted attention of researchers. We evaluated the therapeutic efficacy of melatonin in experimental autoimmune uveitis (EAU), which is a representative animal model of human autoimmune u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d6ec59a-b2e7-5853-ac90-bd03e9c7b7f1
DOI: 10.21203/rs.3.rs-1192974/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Melatonin, an Endogenous Hormone, Modulates Th17 Cells via the Reactive Oxygen Species/TXNIP/HIF-1α Axis to Alleviate Autoimmune UveitisDOI 10.21203/rs.3.rs-1192974/v1Read

Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation by inhibiting Th17-associated pro-inflammatory gene expressionSemantic proximity Read

Irisin Alleviates Autoimmune Uveitis Through Promoting Retinal Microglial M1 to M2 Phenotypic Polarization Mediated by HIF-1α PathwaySemantic proximity Read

MicroRNAs in the regulation of Th17/Treg homeostasis and their potential role in uveitisSemantic proximity Read

Patterns of Inflammation in Experimental Autoimmune Uveitis and Their Correlation to Optical Coherence Tomography Findings in Human UveitisSemantic proximity Read

miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15Semantic proximity Read

Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 AxisSemantic proximity Read

A Novel Tree Shrew Model of Chronic Experimental Autoimmune Uveitis and its Disruptive Application EfficiencySemantic proximity Read

Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axisSemantic proximity Read

iTreg mediated TGF-Β1 therapy improves functional engraftment of cell therapy in rd1 Retinitis Pigmentosa mouse modelSemantic proximity Read

[Uveitis immunopathology: currents knowledge, clinical correlation and research perspectives in the immue-ocular area].Semantic proximity Read

TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populationsSemantic proximity Read

miR‐223‐3p promotes autoreactive T h 17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expressionSemantic proximity Read