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Article

Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression

1 Feb 2009

Abstract excerpt

Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface, degrades visual performance and the quality of life of >10 million people in the United States alone. The primary limitation in the effective treatment of DED is an incomplete understanding of its specific cellular and molecular pathogenic elements. Using a validated mouse model of DED, herein we functionally characterize the...

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PMID: 19155469
DOI: 10.4049/jimmunol.182.3.1247

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