Article

Assessing the impact of mono- and bi-allelic deletions in <i>NRXN1</i> on synaptic function

2026-02-21

Abstract excerpt

Neurexin 1 (NRXN1) is an adhesion protein involved in synapse development and function. Mutations in NRXN1 are strongly linked with neurodevelopmental and psychiatric conditions. Mono-allelic NRXN1 mutations are associated with autistic traits, with increased likelihood of co-occurring intellectual disability. However, mono-allelic mutations have variable penetrance and occur in individuals without neurodevelopm...

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Literature Corpus work: 43e44f49-ca5c-535c-9fc7-4a6dbf8f8127
DOI: 10.64898/2026.02.20.707024

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