Article

Decoding the RNA Splicing Network in HNRNPH2-R114W Brain Organoids

2026-02-09

Abstract excerpt

<h4>ABSTRACT</h4> Autism spectrum disorder and related neurodevelopmental diseases are increasingly linked to disrupted RNA processing during corticogenesis, yet resolving variant-specific mechanisms during early human development remains challenging. We generated isogenic cerebral organoids from a patient iPSC line carrying the HNRNPH2-R114W mutation and its CRISPR-corrected counterpart. Developmental validation...

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Literature Corpus work: 317eff18-3e85-5431-b1fd-01dfeb2ba795
DOI: 10.64898/2026.02.06.704442

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