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Article

Functional Impacts of NRXN1 Knockdown on Neurodevelopment in Stem Cell Models

25 Mar 2013

Abstract excerpt

Exonic deletions in NRXN1 have been associated with several neurodevelopmental disorders, including autism, schizophrenia and developmental delay. However, the molecular mechanism by which NRXN1 deletions impact neurodevelopment remains unclear. Here we used human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) as models to investigate the functional impacts of NRXN1 knockdown. We...

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PMID: 23536886
DOI: 10.1371/journal.pone.0059685

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