Article

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay

2024-03-12

Abstract excerpt

<h4>Summary</h4> Cells need to adapt their transcriptome to quickly match cellular needs in changing environments. mRNA abundance can be controlled by altering both its synthesis and decay. Here we show how, in response to poor nutritional conditions, the bulk of the S. cerevisiae transcriptome undergoes -1 ribosome frameshifts and experiences an accelerated out-of-frame co-translational mRNA decay. Using RNA me...

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Literature Corpus work: 88a735b3-d7fe-5bd5-b284-ed7b9bedbeb4
DOI: 10.1101/2024.03.12.584696

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