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Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

16 Jun 2014

Abstract excerpt

Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are key contributors to heart failure progression. Recently, endothelial-to-mesenchymal transition (EndoMT) and the recruitment of circulating hematopoietic progenitors to the heart have been reported to generate substantial numbers of...

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PMID: 24937432
DOI: 10.1172/jci74783

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