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Article

Molecular networks underlying myofibroblast fate and fibrosis.

Journal of molecular and cellular cardiology - 1 Aug 2016

Stempien-Otero April, Kim Deok-Ho, Davis Jennifer

Abstract excerpt

Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the primary effectors of the heart's fibrotic response. This review is focused on defining myofibroblast physiology, its progenitor...

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Identifiers

PMID: 27167848
DOI: 10.1016/j.yjmcc.2016.05.002
PMCID: PMC5482716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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