KLF4 in Smooth Muscle Cell–Derived Progenitor Cells Is Essential for Angiotensin II–Induced Cardiac Inflammation and Fibrosis

Abstract excerpt

ABSTRACT Cardiac fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) material resulting in cardiac tissue scarring and dysfunction. While it is commonly accepted that myofibroblasts are the major contributors to ECM deposition in cardiac fibrosis, their origin remains debated. By combining lineage tracing and RNA sequencing, our group made the paradigm-shifting discovery that a...

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