Article

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective

2019-09-16

Abstract excerpt

With the accumulation of scientific knowledge of the genetic causes of common diseases and continuous advancement of gene-editing technologies, gene therapies to prevent polygenic diseases may soon become possible. This study endeavored to assess population genetics consequences of such therapies. Computer simulations were used to evaluate the heterogeneity in causal alleles for polygenic diseases that could exist...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eed6e4b9-37f8-51dc-be89-f1a4797ecc78
DOI: 10.1101/770396

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics PerspectiveDOI 10.1101/770396Read

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective.Semantic proximity Read

Quantifying the potential for future gene therapy to lower lifetime risk of polygenic late-onset diseasesSemantic proximity Read

Heritable polygenic editing: the next frontier in genomic medicine?Semantic proximity Read

Gene therapy for polygenic or complex diseasesSemantic proximity Read

Mutations Causing Complex Disease May under Certain Circumstances Be Protective in an Epidemiological Sense.Semantic proximity Read

Assessment of the value of polygenic risk scores in the prevention of disease.Semantic proximity Read

Resilience to dominant genetic disease in the healthy elderlySemantic proximity Read

Evaluating the Potential of Younger Cases and Older Controls Cohorts to Improve Discovery Power in Genome-wide Association Studies of Late-onset DiseasesSemantic proximity Read

Overdispersion of allele frequency differences between populations: implications for meta-analyses of genotypic disease associations.Semantic proximity Read

Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics.Semantic proximity Read

Risks and benefits of population-based genetic testing for Mendelian subsets of common diseases were examined using the example of colorectal cancer risk.Semantic proximity Read

Mendelian inheritance of polygenic diseases: a hypothetical basis for increasing incidence.Semantic proximity Read