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Article

Assessment of the value of polygenic risk scores in the prevention of disease.

Journal of medical screening - 1 Dec 2025

Hingorani Aroon D

Abstract excerpt

It is claimed that polygenic risk scores will transform disease prevention, but a typical polygenic risk score for a common disease only detects 11% of affected individuals at a 5% false positive rate. This level of screening performance is not useful. Claims to the contrary are either due to incorrect interpretation of the data or other influences. Implementation of polygenic risk scores would divert resources...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40928819
DOI: 10.1177/09691413251376444
PMCID: PMC12759097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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