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Article

Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics.

Trends in genetics : TIG - 1 Jun 2018

McGinty Ryan J, Mirkin Sergei M

Abstract excerpt

Over 30 hereditary diseases are caused by the expansion of microsatellite repeats. The length of the expandable repeat is the main hereditary determinant of these disorders. They are also affected by numerous genomic variants that are either nearby (cis) or physically separated from (trans) the repetitive locus, which we review here. These genetic variants have largely been elucidated in model systems using gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29567336
DOI: 10.1016/j.tig.2018.02.005
PMCID: PMC5959756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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