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Article

Heritable polygenic editing: the next frontier in genomic medicine?

Nature - 1 Jan 2025

Visscher Peter M, Gyngell Christopher, Yengo Loic, Savulescu Julian

Abstract excerpt

Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present1-3. To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases. In this...

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PMID: 39779842
DOI: 10.1038/s41586-024-08300-4
PMCID: PMC11735401

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