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Article

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective.

International journal of molecular sciences - 10 Oct 2019

Oliynyk Roman Teo

Abstract excerpt

With the accumulation of scientific knowledge of the genetic causes of common diseases and continuous advancement of gene-editing technologies, gene therapies to prevent polygenic diseases may soon become possible. This study endeavored to assess population genetics consequences of such therapies. Computer simulations were used to evaluate the heterogeneity in causal alleles for polygenic diseases that could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31658652
DOI: 10.3390/ijms20205013
PMCID: PMC6834143

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