Article
A systematic approach to identify functional motifs within vertebrate developmental enhancers.
Developmental biology - 15 Jan 2010
Li Qiang, Ritter Deborah, Yang Nan, Dong Zhiqiang, Li Hao, Chuang Jeffrey H, Guo Su
Abstract excerpt
Uncovering the cis-regulatory logic of developmental enhancers is critical to understanding the role of non-coding DNA in development. However, it is cumbersome to identify functional motifs within enhancers, and thus few vertebrate enhancers have their core functional motifs revealed. Here we report a combined experimental and computational approach for discovering regulatory motifs in developmental enhancers....
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