Article

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

2021-10-07

Abstract excerpt

<h4>ABSTRACT</h4> The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H + ATPase, but other pathways for ion movement are required to dissipate the voltage generated by this process. ClC-7, a Cl - /H + antiporter responsible for lysosomal Cl - permeability, is a candidate to contribute to t...

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Literature Corpus work: aa12b5e8-492e-55b1-b27d-e52281bed2c4
DOI: 10.1101/2021.10.07.463477

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