Article
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.
Cell reports - 29 May 2018
Kim Yongsung, Zheng Xinde, Ansari Zoya, Bunnell Mark C, Herdy Joseph R, Traxler Larissa, Lee Hyungjun, Paquola Apua C M, Blithikioti Chrysanthi, Ku Manching, Schlachetzki Johannes C M, Winkler Jürgen, Edenhofer Frank, Glass Christopher K, Paucar Andres A, Jaeger Baptiste N, Pham Son, Boyer Leah, Campbell Benjamin C, Hunter Tony, Mertens Jerome, Gage Fred H
Abstract excerpt
Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields functional neurons that retain important signs of aging, in contrast to iPSC differentiation. Here, we analyzed mitochondrial features in iNs from individuals of...
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