Article

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design

2025-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. E1E2-based HCV vaccine development has been hindered by the challenge of producing a soluble E1E2 (sE1E2) antigen that faithfully recapitulates the native glycoprotein heterodimer found on virions. Based on available cryo-electron microscopy (cryo-EM) structures, we rationally...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9cb4c441-63eb-5071-8733-3b4f6a972a59
DOI: 10.1101/2025.05.16.654559

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine designDOI 10.1101/2025.05.16.654559Read

Rational design of hepatitis C virus E2 core nanoparticle vaccinesSemantic proximity Read

Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodiesSemantic proximity Read

Structure of the hepatitis C virus E1E2 glycoprotein complexSemantic proximity Read

Hepatitis C Virus E1E2 Structure, Diversity, and Implications for Vaccine DevelopmentSemantic proximity Read

Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigenSemantic proximity Read

A Biologically-validated HCV E1E2 Heterodimer Structural Model.Semantic proximity Read

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modificationSemantic proximity Read

Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteinsSemantic proximity Read

Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance.Semantic proximity Read

Hepatitis C Virus Envelope Glycoproteins: A Balancing Act of Order and DisorderSemantic proximity Read

Computational identification of a multi-peptide vaccine candidate in E2 glycoprotein against diverse Hepatitis C virus genotypes.Semantic proximity Read

Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccinesSemantic proximity Read