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Structure of the hepatitis C virus E1E2 glycoprotein complex

20 Oct 2022

Abstract excerpt

Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The HCV envelope E1 and E2 glycoproteins are essential for viral entry and comprise the primary antigenic target for neutralizing antibody responses. The molecular mechanisms of E1E2 assembly, as well as how the E1E2 heterodimer binds...

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PMID: 36264808
DOI: 10.1126/science.abn9884

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