Article

Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization

2020-04-17

Abstract excerpt

An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of antibodies targeting HCV envelope glycoprotein E2, we designed immunogens to modulate the structure and dynamics of E2 and favor induction of bNAbs in the context of a vaccine. These designs include a point mutation in a key conserved ant...

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Literature Corpus work: 371690a5-2e4c-5752-aa0c-790a57f133a1
DOI: 10.1101/2020.04.15.044073

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