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Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

5 Jul 2023

Abstract excerpt

Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 surface glycoprotein, the development of effective vaccines has been hindered by complications in the biochemical preparation of soluble E1E2 ectodomains. Here, we present a...

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PMID: 37407593
DOI: 10.1038/s41467-023-39659-z

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