Article

Rational design of hepatitis C virus E2 core nanoparticle vaccines

2019-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are critical for cell entry with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a comprehensive strategy for B cell-based HCV vaccine development through E2 optimization and nanoparticle display. We redesigned variable region 2 in a truncated form (tVR2) on E2 cores derived from genotypes 1a and 6a, resulting...

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Literature Corpus work: 793104b9-b0d8-56ff-8c5b-d0092ef7b26e
DOI: 10.1101/717538

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