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Molecular architecture of meiotic pro-crossover factor HEI10 reveals coupling of higher-order assembly and ubiquitin chain formation

2026-05-10

Abstract excerpt

In meiosis, crossovers between homologous chromosomes generate genetic diversity and are required for accurate chromosome segregation, ensuring fertility. In mammals, HEI10 is one of three pro-crossover RING-domain factors implicated in protein modification by ubiquitin and/or SUMO and characterised by their dynamic accumulation at future crossover sites. However, the molecular architecture and enzymatic activity...

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Literature Corpus work
ee2e3b41-c225-5d66-9a04-fce31d37fb4d
DOI
10.64898/2026.05.08.723602
Open publication

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Molecular architecture of meiotic pro-crossover factor HEI10 reveals coupling of higher-order assembly and ubiquitin chain formationDOI 10.64898/2026.05.08.723602
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