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Article

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.

eLife - 18 Jan 2019

West Alan Mv, Rosenberg Scott C, Ur Sarah N, Lehmer Madison K, Ye Qiaozhen, Hagemann Götz, Caballero Iracema, Usón Isabel, MacQueen Amy J, Herzog Franz, Corbett Kevin D

Abstract excerpt

The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that 'axis core proteins' from budding yeast (Red1), mammals (SYCP2/SYCP3), and plants (ASY3/ASY4) are evolutionarily related and play equivalent roles in chromosome axis assembly. We first identify 'closure motifs' in each...

Topics

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Chromosomal Proteins, Non-Histone
DNA Breaks, Double-Stranded
Haploidy
Protein Domains
Protein Interaction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Scattering, Radiation

Synaptonemal Complex

Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 30657449
DOI: 10.7554/eLife.40372
PMCID: PMC6349405

Genes

SYCP2
SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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