Article
E3 ligase Hei10: a multifaceted structure-based signaling molecule with roles within and beyond meiosis.
Genes & development - 15 May 2014
De Muyt Arnaud, Zhang Liangran, Piolot Tristan, Kleckner Nancy, Espagne Eric, Zickler Denise
Abstract excerpt
Human enhancer of invasion-10 (Hei10) mediates meiotic recombination and also plays roles in cell proliferation. Here we explore Hei10's roles throughout the sexual cycle of the fungus Sordaria with respect to localization and effects of null, RING-binding, and putative cyclin-binding (RXL) domain mutations. Hei10 makes three successive types of foci. Early foci form along synaptonemal complex (SC) central...
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