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Transcriptomic Analysis and Multiple Machine Learning Approaches Identify ZDHHC20 and Its Highly Correlated Gene AK5 as Diagnostic Markers in Multiple System Atrophy

2026-02-13

Abstract excerpt

<title>Abstract</title> <p>Background Multiple system atrophy (MSA) is a fatal neurodegenerative disorder lacking effective diagnostic tools. While protein palmitoylation is crucial for neuronal function, its specific role in MSA pathogenesis remains unexplored. Methods We integrated bulk and single-nucleus RNA sequencing (snRNA-seq) data from postmortem MSA brain tissues. Eight machine learning algorithms were...

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Literature Corpus work: 94b5a5c2-b225-5f2c-a45a-97e08df12176
DOI: 10.21203/rs.3.rs-8711800/v1

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