Article
Early genetic counseling and detection of CDH1 mutation in asymptomatic carriers improves survival in hereditary diffuse gastric cancer.
Surgery - 1 Oct 2018
Moslim Maitham A, Heald Brandie, Tu Chao, Burke Carol A, Walsh R Matthew
Abstract excerpt
BACKGROUND: Hereditary diffuse gastric cancer is associated with E-cadherin (CDH1) germline mutations. The implications of CDH1 mutations detected with multigene panels in those without family history of HDGC are uncertain. METHODS: A registry of patients who underwent genetic counseling for CDH1 mutation was queried for the period 2011-2017. RESULTS: Twenty-one patients with CDH1 mutation were identified. The...
Topics
- Adult
- Antigens, CD
- Cadherins
- Female
- Gastrectomy
- Genetic Counseling
- Genetic Testing
- Humans
- Male
- Middle Aged
- Mutation
- Retrospective Studies