Article

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

2021-02-10

Abstract excerpt

<title>Abstract</title> <p>Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein 3 (PNPLA3-I148M). Here, we study how human hepatocytes with PNPLA3 148I and 148M variants engrafted in the livers of chimeric mi...

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Literature Corpus work: ee0134d6-9b95-5588-8773-7beae9754d5e
DOI: 10.21203/rs.3.rs-156250/v1

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