Article

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein 3 (PNPLA3-I148M). Here, we study how human hepatocytes with PNPLA3 148I and 148M variants engrafted in the livers of chimeric mice respon...

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Literature Corpus work: 7a4f1b5f-ba5b-5606-a904-e20d7ae1d836
DOI: 10.1101/2020.11.19.387613

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