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Article

A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.

Journal of virology - 1 Oct 2009

Diaz-Griffero Felipe, Qin Xu-rong, Hayashi Fumiaki, Kigawa Takanori, Finzi Andres, Sarnak Zoe, Lienlaf Maritza, Yokoyama Shigeyuki, Sodroski Joseph

Abstract excerpt

TRIM5alpha is a tripartite motif (TRIM) protein that consists of RING, B-box 2, coiled-coil, and B30.2(SPRY) domains. The TRIM5alpha(rh) protein from rhesus monkeys recognizes the human immunodeficiency virus type 1 (HIV-1) capsid as it enters the host cell and blocks virus infection prior to reverse transcription. HIV-1-restricting ability can be eliminated by disruption of the B-box 2 domain. Changes in the...

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Source

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Identifiers

PMID: 19656869
DOI: 10.1128/JVI.01307-09
PMCID: PMC2753111

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction.PMID 19656869Read ↗

Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction.Semantic proximity Read ↗

Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.Semantic proximity Read ↗

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Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain.Semantic proximity Read ↗

Rhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral core.Semantic proximity Read ↗

Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Semantic proximity Read ↗

Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding.Semantic proximity Read ↗

Retroviral restriction factor TRIM5alpha is a trimer.Semantic proximity Read ↗

The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha.Semantic proximity Read ↗

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An all-atom view into the disordered interaction interface of the TRIM5 <i>α</i> PRYSPRY domain and the HIV capsidSemantic proximity Read ↗

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