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Article

Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.

EMBO molecular medicine - 1 Feb 2018

Winter Sarah, Martin Emmanuel, Boutboul David, Lenoir Christelle, Boudjemaa Sabah, Petit Arnaud, Picard Capucine, Fischer Alain, Leverger Guy, Latour Sylvain

Abstract excerpt

Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T-lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein-Barr virus (EBV) infection. RASGRP1 is a T-lymphocyte-specific nucleotide exchange factor known to activate the pathway of MAP kinases (MAPK). A deleterious homozygous mutation in RASGRP1 leading to the loss RASGRP1 expression was identified in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29282224
DOI: 10.15252/emmm.201708292
PMCID: PMC5801500

Genes

RASGRP1
CTPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.PMID 29282224Read ↗

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