Article
Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.
eLife - 12 Dec 2013
Daley Stephen R, Coakley Kristen M, Hu Daniel Y, Randall Katrina L, Jenne Craig N, Limnander Andre, Myers Darienne R, Polakos Noelle K, Enders Anselm, Roots Carla, Balakishnan Bhavani, Miosge Lisa A, Sjollema Geoff, Bertram Edward M, Field Matthew A, Shao Yunli, Andrews T Daniel, Whittle Belinda, Barnes S Whitney, Walker John R, Cyster Jason G, Goodnow Christopher C, Roose Jeroen P
Abstract excerpt
Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1(Anaef), with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1(Anaef) mice exhibit anti-nuclear autoantibodies and gradually accumulate a CD44(hi) Helios(+) PD-1(+) CD4(+) T cell population that is dependent on B cells. Despite reduced Rasgrp1-Ras-ERK...
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