Article
RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease.
The Journal of allergy and clinical immunology - 1 Aug 2018
Mao Huawei, Yang Wanling, Latour Sylvain, Yang Jing, Winter Sarah, Zheng Jian, Ni Ke, Lv Minmin, Liu Chenjing, Huang Hongmei, Chan Koon-Wing, Pui-Wah Lee Pamela, Tu Wenwei, Fischer Alain, Lau Yu-Lung
Abstract excerpt
BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is a genetic disorder of lymphocyte homeostasis due to impaired apoptosis. It was initially regarded as a very rare disease, but recent studies show that it may be more common than previously thought. Defects in a couple of genes have been identified in a proportion of patients with ALPS, but around one-third of such patients remain undefined genetically....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.