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Functional proteoform group deconvolution reveals a broader spectrum of ibrutinib off-targets

25 Feb 2025

Abstract excerpt

Proteome-wide profiling has revealed that targeted drugs can have complex protein interaction landscapes. However, it's a challenge to profile drug targets while systematically accounting for the dynamic protein variations that produce populations of multiple proteoforms. We address this problem by combining thermal proteome profiling (TPP) with functional proteoform group detection to refine the target landscape...

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PMID: 40000607
DOI: 10.1038/s41467-024-54654-8

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