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The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

27 Jan 2022

Abstract excerpt

Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational modifications. Here, we present the primary structures of ~30,000 unique proteoforms, nearly 10 times more than in previous studies, expressed from 1690 human genes across 21 cell types and plasma from human blood and bone marrow. The results, compiled in the Blood...

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PMID: 35084980
DOI: 10.1126/science.aaz5284

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