Article

Proteoform-level deconvolution reveals a broader spectrum of ibrutinib off-targets

2023-11-14

Abstract excerpt

Over the last decade, proteome-wide mapping of drug interactions has revealed that most targeted drugs bind to not only their intended targets, but additional proteins as well. However, the majority of these studies have focused on analyzing proteins as encoded by their genes, thus neglecting the fact that most proteins exist as dynamic populations of multiple proteoforms. Here, we addressed this problem by combin...

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Literature Corpus work: f2a98814-0753-548f-ae49-0b762c2ebe7c
DOI: 10.1101/2023.11.14.566837

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