Article
Proteomic profiling based classification of CLL provides prognostication for modern therapy and identifies novel therapeutic targets.
Blood cancer journal - 17 Mar 2022
Griffen Ti'ara L, Hoff Fieke W, Qiu Yihua, Lillard James W, Ferrajoli Alessandra, Thompson Philip, Toro Endurance, Ruiz Kevin, Burger Jan, Wierda William, Kornblau Steven M
Abstract excerpt
Protein expression for 384 total and post-translationally modified proteins was assessed in 871 CLL and MSBL patients and was integrated with clinical data to identify strategies for improving diagnostics and therapy, making this the largest CLL proteomics study to date. Proteomics identified six recurrent signatures that were highly prognostic of survival and time to first or second treatment at three levels:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.