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Article

Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer’s disease

2025-03-26

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) is characterized by cognitive decline and neuropathological hallmarks including Aβ plaques and Tau tangles. Emerging evidence indicates oligodendrocyte (OL) dysfunction and demyelination also contribute to disease progression. Here, we analyzed OL markers and inflammatory gene expression in human hippocampal samples at early and late AD stages. In early AD, we observed OL...

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Literature Corpus work
78e0be9f-140a-5071-8cb2-32fddaab2618
DOI
10.1101/2025.03.25.645240
Open publication

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Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer’s diseaseDOI 10.1101/2025.03.25.645240
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