Article

Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targets

2026-05-18

Abstract excerpt

The complement of tumor cell surface proteins, or "surfaceome", is a rich source of potential immunotherapy targets. To move beyond expression-based target discovery, we previously described "structural surfaceomics," combining crosslinking mass spectrometry (XL-MS) with surface protein biotinylation to identify conformation-selective targets. In our prior work, we applied this method to a single model of acute my...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edcd7f49-a401-594c-8907-b2dec185ffb1
DOI: 10.64898/2026.05.15.721813

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targetsDOI 10.64898/2026.05.15.721813Read

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy targetSemantic proximity Read

Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy targetSemantic proximity Read

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistanceSemantic proximity Read

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clustersSemantic proximity Read

The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapySemantic proximity Read

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodiesSemantic proximity Read

AI supported in silico screening of chimeric antigen receptor therapy targetsSemantic proximity Read

Mapping targetable sites on the human surfaceome for the design of novel bindersSemantic proximity Read

Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitorsSemantic proximity Read

Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemiaSemantic proximity Read

Quantitative interactome analysis reveals a chemoresistant edgotype.Semantic proximity Read

Proximity-Informed Graph Learning Defines Spatial Protein Communities for Tumor-Associated Proximity Antigen DiscoverySemantic proximity Read