Article

Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

2023-08-26

Abstract excerpt

Monoclonal antibodies targeting the immune checkpoint PD-1 have provided significant clinical benefit across a number of solid tumors, with differences in efficacy and toxicity profiles possibly related to their intrinsic molecular properties. Here, we report that camrelizumab and cemiplimab engage PD-1 through interactions with its fucosylated glycan. Using a combination of protein and cell glycoengineering, we d...

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Literature Corpus work: d8b41bd1-f480-5fec-b512-ac98ad9fde31
DOI: 10.1101/2023.08.25.554811

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